Bendectin and birth defects II: Ecological analyses
نویسندگان
چکیده
منابع مشابه
Bendectin and birth defects. II: Ecological analyses.
BACKGROUND Bendectin was the primary pharmaceutical treatment of nausea and vomiting of pregnancy (NVP) in the United States until the early 1980s. Its manufacture was then discontinued after public allegations that it was causing birth defects. Subsequently, meta-analyses of the many epidemiological cohort and case/control studies used to examine that hypothesis have demonstrated the absence o...
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The study published in this issue of Birth Defects Research Part A, “Bendectin and Birth Defects: Ecological Analysis,” by Kutcher et al. (2002) deals with two aspects pertaining to the effects of Bendectin. It is an excellent research article. The first area investigated was related to the question as to whether Bendectin was a human teratogen based on ecological analysis. The second area inve...
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Evidence of human birth defects dating back over three thousand years is reported in archeological literature. Excavated ruins of ancient Babylon revealed detailed reports of infant defects.1 Achondroplastic dwarfs (failure to develop healthy cartilage at the ends of the long bones, resulting in a form of congenital dwarfism) have been unearthed in ancient Egyptian tombs. Pictures drawn on anci...
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The definition of colic was stated in the introductory lines; the healthy babies had expressed colic of three to 13 hours' duration daily, only cases 2 and 6 occasionally having had daily colic of shorter duration than three hours: washout periods have no relevance in this context: any food between treatments might produce carry over effect; professional statisticians were consulted about prope...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2003
ISSN: 1542-0752,1542-0760
DOI: 10.1002/bdra.10034